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Article

Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway.

Journal of cancer research and clinical oncology - 1 Jan 2016

Chang Ligong, Wu Peng, Senthilkumar Ravichandran, Tian Xiaoqiang, Liu Hui, Shen Xia, Tao Zijian, Huang Peilin

Abstract excerpt

PURPOSE: Altered cellular metabolism has received increased attention as an important hallmark of cancer. Activation of FASN has been found to be involved in many human tumors. Despite extensive research in FASN function on cancer, the underlying mechanism is not entirely understood yet. METHODS: Cerulenin was used to suppress the FASN expression in human colorectal cancer cell lines (HT29 and LoVo). Expression...

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Identifiers

PMID: 26109148
DOI: 10.1007/s00432-015-2000-8

Genes

FASN
AZGP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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