Article
No association between estrogen receptor gene polymorphisms and premature thelarche in girls.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Oct 2017
Lee Hae Sang, Yoon Jong Seo, So Cheol Hwan, Kim Kyung Hee, Hwang Jin Soon
Abstract excerpt
OBJECTIVE: Premature thelarche (PT) is a benign, nonprogressive condition defined as isolated breast development. While the pathophysiology of PT remains unclear, increased sensitivity to estrogen may cause PT. The aim of this study was to investigate the association between polymorphisms in the estrogen receptor alpha (ERα) gene and PT in girls. METHODS: In this case-control study, we examined 96 girls referred...
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