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Article

A case of premature thelarche with no central cause or genetic variants within the estrogen receptor signaling pathway.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Aug 2009

Hartmaier R J, Walenkamp M J E, Richter A S, Wang J, Katzenellenbogen B S, Oesterreich S, Wit J M

Abstract excerpt

BACKGROUND: Premature thelarche is defined as breast development before 8 years of age. This is most often caused by central hormone disregulation and is accompanied by concurrent bone maturation. However, we present a case of premature thelarche with concurrent bone maturation without central hormone disregulation. Genes within the estrogen signaling pathway were examined for genetic changes which might be...

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Source

Identifiers

PMID: 19845126
DOI: 10.1515/jpem.2009.22.8.751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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