Article
The MET oncogene transforms human primary bone-derived cells into osteosarcomas by targeting committed osteo-progenitors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2012
Dani Nadia, Olivero Martina, Mareschi Katia, van Duist Marjan Maria, Miretti Silvia, Cuvertino Sara, Patané Salvatore, Calogero Raffaele, Ferracini Riccardo, Scotlandi Katia, Fagioli Franca, Di Renzo Maria Flavia
Abstract excerpt
The MET oncogene is aberrantly overexpressed in human osteosarcomas. We have previously converted primary cultures of human bone-derived cells into osteosarcoma cells by overexpressing MET. To determine whether MET transforms mesenchymal stem cells or committed progenitor cells, here we characterize distinct MET overexpressing osteosarcoma (MET-OS) clones using genome-wide expression profiling, cytometric...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.