Article
Prospective study of the accuracy of EGFR mutational analysis by high-resolution melting analysis in small samples obtained from patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2008
Fukui Tomoya, Ohe Yuichiro, Tsuta Koji, Furuta Koh, Sakamoto Hiromi, Takano Toshimi, Nokihara Hiroshi, Yamamoto Noboru, Sekine Ikuo, Kunitoh Hideo, Asamura Hisao, Tsuchida Takaaki, Kaneko Masahiro, Kusumoto Masahiko, Yamamoto Seiichiro, Yoshida Teruhiko, Tamura Tomohide
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) mutations, especially in-frame deletions in exon 19 (DEL) and a point mutation in exon 21 (L858R), predict gefitinib sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we verified the accuracy of EGFR mutation analysis...
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