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Article

High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies.

BMC cancer - 21 May 2008

Do Hongdo, Krypuy Michael, Mitchell Paul L, Fox Stephen B, Dobrovic Alexander

Abstract excerpt

BACKGROUND: Epithelial growth factor receptor (EGFR) and KRAS mutation status have been reported as predictive markers of tumour response to EGFR inhibitors. High resolution melting (HRM) analysis is an attractive screening method for the detection of both known and unknown mutations as it is rapid to set up and inexpensive to operate. However, up to now it has not been fully validated for clinical samples when...

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Identifiers

PMID: 18495026
DOI: 10.1186/1471-2407-8-142
PMCID: PMC2408599

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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