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Article

Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease.

Scientific reports - 21 Apr 2017

Qiu Yiguo, Yu Hongsong, Zhu Yunyun, Ye Zi, Deng Jing, Su Wencheng, Cao Qingfeng, Yuan Gangxiang, Kijlstra Aize, Yang Peizeng

Abstract excerpt

Aberrant methylation change of IRF8 confers risk to various tumors, and abnormal expression of IRF8 is involved in many autoimmune diseases, including ocular Behcet's disease. However, whether the methylation change of IRF8 is associated with Vogt-Koyanagi-Harada (VKH) disease remains unknown. In the present study, we found a decreased IRF8 mRNA expression in association with a higher methylation level in...

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Identifiers

PMID: 28432342
DOI: 10.1038/s41598-017-01249-7
PMCID: PMC5430771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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