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Article

Two Genetic Variations in the IRF8 region are associated with Behçet's disease in Han Chinese.

Scientific reports - 22 Jan 2016

Jiang Yanni, Wang Hong, Yu Hongsong, Li Lin, Xu Dengfeng, Hou Shengping, Kijlstra Aize, Yang Peizeng

Abstract excerpt

Several modulatory factors in the TLR signaling pathway including IRF3, IRF7, IRF8, TRIM20, MYD88 and NF-κB1 have been associated with autoimmune disease. In this study, we investigated the association of 13 SNPs for these genes with Behçet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome using a polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay. Haplotype and linkage...

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Identifiers

PMID: 26794091
DOI: 10.1038/srep19651
PMCID: PMC4726413

Genes

MYD88

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