Article
Polymorphism of IFN-gamma gene and Vogt-Koyanagi-Harada disease.
Molecular vision - 21 Dec 2007
Horie Yukihiro, Kitaichi Nobuyoshi, Takemoto Yuko, Namba Kenichi, Yoshida Kazuhiko, Hirose Shigeto, Hasumi Yukiko, Ota Masao, Inoko Hidetoshi, Mizuki Nobuhisa, Ohno Shigeaki
Abstract excerpt
PURPOSE: Interferon-gamma (IFN-gamma) is a key cytokine in inflammatory disorders. Elevated aqueous and serum levels of IFN-gamma levels have been reported to be elevated in patients with Vogt-Koyanagi-Harada (VKH) disease. The aim of this study was to determine the IFN-gamma gene polymorphisms in VKH disease. METHODS: The study involved 136 VKH patients and 176 healthy controls, who were genotyped for functional...
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