Article
Nuclear Proximity of Mtr4 to RNA Exosome Restricts DNA Mutational Asymmetry.
Cell - 20 Apr 2017
Lim Junghyun, Giri Pankaj Kumar, Kazadi David, Laffleur Brice, Zhang Wanwei, Grinstein Veronika, Pefanis Evangelos, Brown Lewis M, Ladewig Erik, Martin Ophélie, Chen Yuling, Rabadan Raul, Boyer François, Rothschild Gerson, Cogné Michel, Pinaud Eric, Deng Haiteng, Basu Uttiya
Abstract excerpt
The distribution of sense and antisense strand DNA mutations on transcribed duplex DNA contributes to the development of immune and neural systems along with the progression of cancer. Because developmentally matured B cells undergo biologically programmed strand-specific DNA mutagenesis at focal DNA/RNA hybrid structures, they make a convenient system to investigate strand-specific mutagenesis mechanisms. We...
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