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Article

Patient derived cancer-associated fibroblasts from non-small cell lung cancer undergo phenotypic drift in culture

10 Jul 2025

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) are the predominant cell type in the stroma of many solid organ malignancies, including non-small cell lung cancer (NSCLC). They exhibit considerable phenotypic and functional heterogeneity and are widely used in functional assays and co-culture models. CAF research frequently involves the in vitro expansion and maintenance of CAFs to facilitate functional assays...

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PMID: 40640541
DOI: 10.1038/s44276-025-00159-w

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