Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.

doi:10.1002/art.40122

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Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jul 2017

Frémond Marie-Louise, Uggenti Carolina, Van Eyck Lien, Melki Isabelle, Bondet Vincent, Kitabayashi Naoki, Hertel Christina, Hayday Adrian, Neven Bénédicte, Rose Yoann, Duffy Darragh, Crow Yanick J, Rodero Mathieu P

Abstract excerpt

OBJECTIVE: Gain-of-function mutations in TMEM173, encoding the stimulator of interferon (IFN) genes (STING) protein, underlie a novel type I interferonopathy that is minimally responsive to conventional immunosuppressive therapies and associated with high frequency of childhood morbidity and mortality. STING gain-of-function causes constitutive oversecretion of IFN. This study was undertaken to determine the...

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Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.

Abstract excerpt

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