Article

STK4 deficiency underlies impaired interferon signaling and T cell immunity

2021-03-22

Abstract excerpt

<title>Abstract</title> <p>Purpose. Human serine/threonine kinase 4 (STK4) deficiency is a rare, autosomal recessive genetic disorder leading to combined immunodeficiency. The extent to which STK4 deficiency impairs immune signaling and host defenses is unclear. We assessed the functional consequences of a novel, homozygous nonsense STK4 mutation (NM_006282.2:c.871C>T, p.Arg291*) found in a pediatric patient by c...

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Literature Corpus work: 562f7542-ba61-5b49-a6db-15778fc0eac7
DOI: 10.21203/rs.3.rs-328827/v1

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