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Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN

24 Jun 2021

Abstract excerpt

The innate immune and host-protective responses to viruses, such as the airway pathogen human metapneumovirus (HMPV), depend on interferons (IFNs) that is induced through TANK-binding kinase 1 (TBK1) and IFN regulatory factors (IRFs). The transcription factor IRF1 is important for host resistance against several viruses and has a key role in induction of IFN-λ at mucosal surfaces. In most cell types IRF1 is...

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PMID: 34248923
DOI: 10.3389/fimmu.2021.563336

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