Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitis

7 Nov 2023

Abstract excerpt

The mechanisms underlying susceptibility to recurrent herpes simplex virus type 2 (HSV-2) meningitis remain incompletely understood. In a patient experiencing multiple episodes of HSV-2 meningitis, we identified a monoallelic variant in the IKBKE gene, which encodes the IKKε kinase involved in induction of antiviral IFN genes. Patient cells displayed impaired induction of IFN-β1 (IFNB1) expression upon infection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37937644
DOI: 10.1172/jci.insight.173066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An IKBKE variant conferring functional cGAS/STING pathway deficiency and susceptibility to recurrent HSV-2 meningitisPMID 37937644Read ↗

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.Semantic proximity Read ↗

The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brainSemantic proximity Read ↗

Herpes simplex encephalitis in a patient with a distinctive form of inherited IFNAR1 deficiencySemantic proximity Read ↗

Whole-Exome Sequencing of Patients With Recurrent HSV-2 Lymphocytic Mollaret MeningitisSemantic proximity Read ↗

Impaired STING Activation Due to a Variant in the E3 Ubiquitin Ligase AMFR in a Patient with Severe VZV Infection and Hemophagocytic LymphohistiocytosisSemantic proximity Read ↗

Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.Semantic proximity Read ↗

HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection.Semantic proximity Read ↗

Human retinoic acid-inducible gene I (RIG-I) deficiency associated with susceptibility to classic Kaposi sarcoma.Semantic proximity Read ↗

Brief Report: Blockade of TANK-Binding Kinase 1/IKKɛ Inhibits Mutant Stimulator of Interferon Genes (STING)-Mediated Inflammatory Responses in Human Peripheral Blood Mononuclear Cells.Semantic proximity Read ↗

Human RIG-I deficiency confers susceptibility to Kaposi Sarcoma via loss of latency controlSemantic proximity Read ↗

IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation.Semantic proximity Read ↗

Impaired STING activation due to a variant in the E3 ubiqitin ligase AMFR in a patient with severe VZV infection and hemophagocytic lymphohistiocytosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.