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Herpes simplex virus 1 encodes a STING antagonist that can be therapeutically targeted

1 Apr 2025

Abstract excerpt

Herpes simplex virus 1 (HSV-1) is a ubiquitous human pathogen that causes serious symptoms and is known for its strong interactions with host immunity. Here, we revealed that the HSV-1-encoded UL38 is a stimulator of interferon genes (STING) antagonist that interacts with STING to abrogate the STING-TANK-binding kinase 1 (TBK1)-interferon regulatory factor 3 (IRF3) interaction, thereby suppressing cyclic GMP-AMP...

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PMID: 40239620
DOI: 10.1016/j.xcrm.2025.102051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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