Article
Longevity is impacted by growth hormone action during early postnatal period.
eLife - 4 Jul 2017
Sun Liou Y, Fang Yimin, Patki Amit, Koopman Jacob Je, Allison David B, Hill Cristal M, Masternak Michal M, Darcy Justin, Wang Jian, McFadden Samuel, Bartke Andrzej
Abstract excerpt
Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate control mice in a genotype and sex-specific manner. Studies in a separate cohort of Ames dwarf mice show that this short period of the GH exposure during early...
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