Functional analysis implicating the SNP rs61552325 in ERBB2 as an effector for androgen-insensitive prostate cancer cell invasion.

doi:10.18632/oncotarget.16807

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Article

Functional analysis implicating the SNP rs61552325 in ERBB2 as an effector for androgen-insensitive prostate cancer cell invasion.

Oncotarget - 16 May 2017

Xin Xianxiang, Gu Yinmin, Chen Yang, Huang Yuanjie, Mo Zengnan, Hu Yanling

Abstract excerpt

BACKGROUND: As one of the most common cancers in men, the pathogenesis of prostate cancer has been widely researched. Aberrant activation of the erb-b2 receptor tyrosine kinase 2 (ERBB2) has been found to play a critical role in metastatic prostate cancer. In our previous study, we demonstrated that rs61552325 (Pro1140Ala) located in ERBB2 is strongly correlated to prostate cancer. Therefore, we initially studied...

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PMID: 28422721
DOI: 10.18632/oncotarget.16807
PMCID: PMC5464908

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ERBB2

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