TMPRSS2 rs12329760 variant as a prognostic marker for prostate cancer progression.

doi:10.1007/s11033-026-11442-5

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Article

TMPRSS2 rs12329760 variant as a prognostic marker for prostate cancer progression.

Molecular biology reports - 13 Jan 2026

Elghazali Khaoula, Najih Mouad, Sakhi Zineb, Ennaji Youssef, Laaraqui Abdelilah, Tagajdid Rida, Amine Abdessamad, Ennaji Moulay Mustapha

Abstract excerpt

BACKGROUND: TMPRSS2, a transmembrane serine protease and common partner in oncogenic TMPRSS2-ERG fusions, is regulated by androgen receptors and is implicated in prostate tumorigenesis. The nonsynonymous SNP rs12329760 (C > T; Val160Met) has been hypothesized to alter TMPRSS2 proteolytic activity, potentially enhancing AR signaling and contributing to aggressive tumor behavior. However, data on this variant in...

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PMID: 41528570
DOI: 10.1007/s11033-026-11442-5

Genes

TMPRSS2
ERG
AR

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