Article
[Genotype of the GNB3 C825T polymorphism, A risk factor for the development and course of prostate cancer?].
Der Urologe. Ausg. A - 1 Sept 2011
Eisenhardt A, Scherag A, Kempin M, Jöckel K H, Rübben H
Abstract excerpt
BACKGROUND: G protein-mediated signal transduction plays a key role in pathways of metastasis. A C/T polymorphism (dbSNP rs5443) at position 825 of the GNB3 gene has been described. Previous studies demonstrated an association between the GNB3 C825T genotype and different cancer entities. PATIENTS AND METHODS: In this report genotyping for this marker was performed in 235 prostate cancer patients and 111 healthy...
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