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Article

HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study.

The Lancet. Oncology - 1 Oct 2016

Hearn Jason W D, AbuAli Ghada, Reichard Chad A, Reddy Chandana A, Magi-Galluzzi Cristina, Chang Kai-Hsiung, Carlson Rachel, Rangel Laureano, Reagan Kevin, Davis Brian J, Karnes R Jeffrey, Kohli Manish, Tindall Donald, Klein Eric A, Sharifi Nima

Abstract excerpt

BACKGROUND: HSD3B1 (1245A>C) has been mechanistically linked to castration-resistant prostate cancer because it encodes an altered enzyme that augments dihydrotestosterone synthesis from non-gonadal precursors. We postulated that men inheriting the HSD3B1 (1245C) allele would exhibit resistance to androgen-deprivation therapy (ADT). METHODS: In this multicohort study, we determined HSD3B1 genotype retrospectively...

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Identifiers

PMID: 27575027
DOI: 10.1016/S1470-2045(16)30227-3
PMCID: PMC5135009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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