Article
Molecular study of the PCA3 gene: genotypic analysis of PCA3 polymorphism -845G>A and metastatic prostate cancer.
Genetic testing and molecular biomarkers - 1 May 2012
Fontenete Silvia, Nogueira Augusto, Pina Francisco, Lobo Francisco, Fraga Avelino, Calais da Silva Fernando, Medeiros Rui
Abstract excerpt
AIMS: The prostate cancer gene 3 (PCA3) is a prostate-specific, non-protein-coding RNA. It is overexpressed in prostate cancer compared with the normal prostate and has a negative expression in other tissues. This case-control study sought to analyze the frequency of the polymorphism PCA3 -845 G>A in participants without prostate cancer and patients with metastatic prostate cancer. RESULTS: Carriers of GA and AA...
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