Article
Sequential evaluation of CALR mutant burden in patients with myeloproliferative neoplasms.
Oncotarget - 16 May 2017
Cavalloni Chiara, Rumi Elisa, Ferretti Virginia V, Pietra Daniela, Roncoroni Elisa, Bellini Marta, Ciboddo Michele, Casetti Ilaria C, Landini Benedetta, Fugazza Elena, Troletti Daniela, Astori Cesare, Cazzola Mario
Abstract excerpt
We investigated the variation of CALR-mutant burden during follow-up in 105 CALR-mutant MPN and compared it to the variation of JAK2-mutant burden in 226 JAK2-mutant MPN.The median allele burden at last evaluation was significantly higher than at first evaluation in essential thrombocythemia (ET) (49.5% vs 45%, P < .001) but not in primary myelofibrosis (PMF) (52% vs 51%, P 0.398). Median values of slope were...
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