Sequential mutational evaluation of CALR -mutated myeloproliferative neoplasms with thrombocytosis reveals an association between CALR allele burden evolution and disease progression.

doi:10.1111/bjh.16276

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Article

Sequential mutational evaluation of CALR -mutated myeloproliferative neoplasms with thrombocytosis reveals an association between CALR allele burden evolution and disease progression.

British journal of haematology - 1 Mar 2020

Cottin Laurane, Riou Jérémie, Orvain Corentin, Ianotto Jean Christophe, Boyer Françoise, Renard Maxime, Truchan-Graczyk Matgorzata, Murati Anne, Jouanneau-Courville Rébecca, Allangba Olivier, Mansier Olivier, Burroni Barbara, Rousselet Marie-Christine, Quintin-Roué Isabelle, Martin Antoine, Sadot-Lebouvier Sophie, Delneste Yves, Chrétien Jean-Marie, Hunault-Berger Mathilde, Blanchet Odile, Lippert Eric, Ugo Valérie, Luque Paz Damien

Abstract excerpt

In myeloproliferative neoplasms (MPN), JAK2V617F allele burden measurement has an impact on prognosis that helps in patient monitoring. Less is known about its usefulness in CALR-mutated cases. Additional mutations found by next-generation sequencing have also shown an impact on prognosis that may drive therapeutic choices, especially in myelofibrosis, but few studies focused on CALR-mutated patients. We...

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PMID: 31710700
DOI: 10.1111/bjh.16276

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