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Article

Differential Dynamics of CALR Mutant Allele Burden in Myeloproliferative Neoplasms during Interferon Alfa Treatment.

PloS one - 1 Jan 2016

Kjær Lasse, Cordua Sabrina, Holmström Morten O, Thomassen Mads, Kruse Torben A, Pallisgaard Niels, Larsen Thomas S, de Stricker Karin, Skov Vibe, Hasselbalch Hans C

Abstract excerpt

Discovery of somatic mutations in the calreticulin gene (CALR) has identified a subgroup of Philadelphia-negative chronic myeloproliferative neoplasms (MPN) with separate haematological characteristics and prognosis. CALR mutations serve as novel markers both of diagnostic value and as targets for monitoring molecular responses during therapy. Interferon-α (IFN) selectively targets the malignant clone in a subset...

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Source

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Identifiers

PMID: 27764253
DOI: 10.1371/journal.pone.0165336
PMCID: PMC5072743

Genes

CALR
ELN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential Dynamics of CALR Mutant Allele Burden in Myeloproliferative Neoplasms during Interferon Alfa Treatment.PMID 27764253Read ↗

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