Article
Stratified polygenic risk prediction model with application to CAGI bipolar disorder sequencing data.
Human mutation - 1 Sept 2017
Wang Maggie Haitian, Chang Billy, Sun Rui, Hu Inchi, Xia Xiaoxuan, Wu William Ka Kei, Chong Ka Chun, Zee Benny Chung-Ying
Abstract excerpt
Genetic data consists of a wide range of marker types, including common, low-frequency, and rare variants. Multiple genetic markers and their interactions play central roles in the heritability of complex disease. In this study, we propose an algorithm that uses a stratified variable selection design by genetic architectures and interaction effects, achieved by a dataset-adaptive W-test. The polygenic sets in all...
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