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Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART

17 Apr 2017

Abstract excerpt

Little is known about the fraction of human immunodeficiency virus type 1 (HIV-1) proviruses that express unspliced viral RNA in vivo or about the levels of HIV RNA expression within single infected cells. We developed a sensitive cell-associated HIV RNA and DNA single-genome sequencing (CARD-SGS) method to investigate fractional proviral expression of HIV RNA (1.3-kb fragment of p6, protease, and reverse...

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PMID: 28416661
DOI: 10.1073/pnas.1617961114

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