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Article

Broad activation of latent HIV-1 in vivo

8 Sept 2016

Abstract excerpt

The 'shock and kill' approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) with targeted immunotherapy to purge infected cells. The administration of LRAs (panobinostat or vorinostat) to HIV-1-infected individuals on antiretroviral therapy induces a significant increase in cell-associated unspliced (CA-US) HIV-1 RNA...

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PMID: 27605062
DOI: 10.1038/ncomms12731

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