Article
Spontaneous HIV expression during suppressive ART is associated with the magnitude and function of HIV-specific CD4+ and CD8+ T cells.
Cell host & microbe - 13 Sept 2023
Dubé Mathieu, Tastet Olivier, Dufour Caroline, Sannier Gérémy, Brassard Nathalie, Delgado Gloria-Gabrielle, Pagliuzza Amélie, Richard Corentin, Nayrac Manon, Routy Jean-Pierre, Prat Alexandre, Estes Jacob D, Fromentin Rémi, Chomont Nicolas, Kaufmann Daniel E
Abstract excerpt
Spontaneous transcription and translation of HIV can persist during suppressive antiretroviral therapy (ART). The quantity, phenotype, and biological relevance of this spontaneously "active" reservoir remain unclear. Using multiplexed single-cell RNAflow-fluorescence in situ hybridization (FISH), we detect active HIV transcription in 14/18 people with HIV on suppressive ART, with a median of 28/million CD4+...
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