Article
Utility of multigene panel next-generation sequencing in routine clinical practice for identifying genomic alterations in newly diagnosed metastatic nonsmall cell lung cancer.
Internal medicine journal - 1 Apr 2024
Nindra Udit, Pal Abhijit, Bray Victoria, Yip Po Y, Tognela Annette, Roberts Tara L, Becker Therese M, Williamson Jonathon, Farzin Mahtab, Li Jing J, Lea Vivienne, Hagelamin Abeer, Ng Weng, Wang Bin, Lee C Soon, Chua Wei
Abstract excerpt
BACKGROUND: The standard of care in newly diagnosed metastatic non-small cell lung cancer (NSCLC) is to test for aberrations in three genes for driver mutations - ALK, ROS1 and epidermal growth factor receptor (EGFR) - and also for immunohistochemistry to be performed for programmed death-ligand 1 expression level. Next-generation sequencing (NGS), with or without RNA fusion testing, is increasingly used in...
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