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Article

Transcriptional networks are associated with resistance to Mycobacterium tuberculosis infection

17 Apr 2017

Abstract excerpt

RATIONALE: Understanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV. OBJECTIVES: To compare the early transcriptional response of M.tb-infected monocytes between Ugandan household contacts of tuberculosis patients who demonstrate clinical resistance to M.tb infection (cases) and matched...

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PMID: 28414762
DOI: 10.1371/journal.pone.0175844

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