Article
Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling.
Nature cell biology - 1 May 2017
Reilein Amy, Melamed David, Park Karen Sophia, Berg Ari, Cimetta Elisa, Tandon Nina, Vunjak-Novakovic Gordana, Finkelstein Sarah, Kalderon Daniel
Abstract excerpt
Adult stem cells provide a renewable source of differentiated cells for a wide variety of tissues and generally give rise to multiple cell types. Basic principles of stem cell organization and regulation underlying this behaviour are emerging. Local niche signals maintain stem cells, while different sets of signals act outside the niche to diversify initially equivalent stem cell progeny. Here we show that...
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