Article
Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary.
The Journal of cell biology - 25 Aug 2008
O'Reilly Alana M, Lee Hsiu-Hsiang, Simon Michael A
Abstract excerpt
Adult stem cells are maintained in specialized microenvironments called niches, which promote self-renewal and prevent differentiation. In this study, we show that follicle stem cells (FSCs) in the Drosophila melanogaster ovary rely on cues that are distinct from those of other ovarian stem cells to establish and maintain their unique niche. We demonstrate that integrins anchor FSCs to the basal lamina, enabling...
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