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Article

Rationally designed turn promoting mutation in the amyloid-β peptide sequence stabilizes oligomers in solution.

PloS one - 1 Jan 2011

Rajadas Jayakumar, Liu Corey W, Novick Paul, Kelley Nicholas W, Inayathullah Mohammed, Lemieux Melburne C, Pande Vijay S

Abstract excerpt

Enhanced production of a 42-residue beta amyloid peptide (Aβ(42)) in affected parts of the brain has been suggested to be the main causative factor for the development of Alzheimer's Disease (AD). The severity of the disease depends not only on the amount of the peptide but also its conformational transition leading to the formation of oligomeric amyloid-derived diffusible ligands (ADDLs) in the brain of AD...

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Identifiers

PMID: 21799748
DOI: 10.1371/journal.pone.0021776
PMCID: PMC3142112

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