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Article

Decoding the genetic basis of demyelination: Prediction of potential pathogenic coding and regulatory noncoding MBP SNPs in multiple sclerosis.

PloS one - 1 Jan 2026

Alwabran Arwa Ibrahim, Aldoseri Ghalia Mahfod, Aldoseri Ghanem Mahfod, Mohager Samah O, Aldoseri Mobarak Mahfod, Kamal Ebtihal

Abstract excerpt

BACKGROUND: The Myelin Basic Protein (MBP) gene is essential for myelin sheath formation in the central nervous system. Coding and noncoding single-nucleotide polymorphisms (SNPs) can impair the protein structure and function, contributing to demyelinating diseases exemplified by multiple sclerosis. This study aimed to assess the impact of SNPs in the MBP gene on protein structure and function. METHODS: We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42166461
DOI: 10.1371/journal.pone.0347598
PMCID: PMC13193510

Genes

MBP

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