A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis.

doi:10.3389/fimmu.2020.00771

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Article

A Polymorphism Within the MBP Gene Is Associated With a Higher Relapse Number in Male Patients of Multiple Sclerosis.

Frontiers in immunology - 1 Jan 2020

Espino-Paisán Laura, Agudo-Jiménez Teresa, Rosales-Martínez Isabel, López-Cotarelo Pilar, García-Martínez María Ángel, Domínguez-Mozo María Inmaculada, Pérez-Pérez Silvia, Dieli-Crimi Romina, Comabella Manuel, Urcelay Elena, Álvarez-Lafuente Roberto

Abstract excerpt

Myelin basic protein (MBP) is thought to be one of the key autoantigens in multiple sclerosis (MS) development. A recent study described the association of the single nucleotide polymorphism (SNP) rs12959006, within the MBP gene, with a higher risk of relapse and worse prognosis. We aim at studying potential associations of this SNP to MS in an independent population. Clinical data of the first 5 years of the...

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PMID: 32431704
DOI: 10.3389/fimmu.2020.00771
PMCID: PMC7214696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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