Article
HLA-Bw4 80(T) and multiple HLA-Bw4 copies combined with KIR3DL1 associate with spontaneous clearance of HCV infection in people who inject drugs.
Journal of hepatology - 1 Sept 2017
Thöns Christine, Senff Tina, Hydes Theresa J, Manser Angela R, Heinemann Falko M, Heinold Andreas, Heilmann Martin, Kim Arthur Y, Uhrberg Markus, Scherbaum Norbert, Lauer Georg M, Khakoo Salim I, Timm Jörg
Abstract excerpt
BACKGROUND & AIMS: Natural killer (NK) cell function is regulated by inhibitory and activating receptors including killer cell immunoglobulin-like receptors (KIRs). Here, we analyzed the impact of different KIR/KIR-ligand genotypes on the outcome of hepatitis C virus (HCV) infection in people who inject drugs (PWID). METHODS: KIR/KIR-ligand genotypes associated with spontaneous clearance of HCV infection were...
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