Article
KIR3DL1-HLA-Bw4 combination and IL28B polymorphism predict response to Peg-IFN and ribavirin with and without telaprevir in chronic hepatitis C.
Human immunology - 1 Aug 2014
Umemura Takeji, Ota Masao, Katsuyama Yoshihiko, Wada Shuichi, Mori Hiromitsu, Maruyama Atsushi, Shibata Soichiro, Nozawa Yuichi, Kimura Takefumi, Morita Susumu, Joshita Satoru, Komatsu Michiharu, Matsumoto Akihiro, Kamijo Atsushi, Kobayashi Masakazu, Takamatsu Masato, Yoshizawa Kaname, Kiyosawa Kendo, Tanaka Eiji
Abstract excerpt
Natural killer cells play a key role in the immune control of viral infections. Killer immunoglobulin-like receptors (KIRs) regulate natural killer cell activation and inhibition through the recognition of their cognate HLA class I ligands. We assessed the predictive factors of a sustained virological response (SVR) in 200 Japanese patients with chronic genotype 1b hepatitis C who were treated with telaprevir...
Topics
- Aged
- Antiviral Agents
- Drug Therapy, Combination
- Female
- Gene Expression
- Genotype
- HLA-B Antigens
- Hepacivirus
- Hepatitis C, Chronic