Article
Contribution of genes for killer cell immunoglobulin-like receptors (KIR) to the susceptibility to chronic hepatitis C virus infection and to viremia.
Human immunology - 1 Mar 2015
Kuśnierczyk Piotr, Mozer-Lisewska Iwona, Zwolińska Katarzyna, Kowala-Piaskowska Arleta Elżbieta, Bura Maciej, Bereszyńska Iwona, Pauli Anna, Żeromski Jan
Abstract excerpt
BACKGROUND: Natural killer (NK) cells are an important element of innate immunity against viruses, although their numbers decrease in the liver during chronic HCV infection. NK cells express a large panel of inhibitory and activating receptors. The most polymorphic of these are killer cell immunoglobulin-like receptors (KIRs) which are encoded by multiple genes that may be present or absent in given individuals...
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