Article
Generation of Peroxisome-Deficient Somatic Animal Cell Mutants.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017
Okumoto Kanji, Fujiki Yukio
Abstract excerpt
Cell mutants with a genetic defect affecting various cellular phenotypes are widely utilized as a powerful tool in genetic, biochemical, and cell biological research. More than a dozen complementation groups of animal somatic mutant cells defective in peroxisome biogenesis have been successfully isolated in Chinese hamster ovary (CHO) cells and used as a model system reflecting fatal human severe genetic...
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