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Article

Generation of Peroxisome-Deficient Somatic Animal Cell Mutants.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Okumoto Kanji, Fujiki Yukio

Abstract excerpt

Cell mutants with a genetic defect affecting various cellular phenotypes are widely utilized as a powerful tool in genetic, biochemical, and cell biological research. More than a dozen complementation groups of animal somatic mutant cells defective in peroxisome biogenesis have been successfully isolated in Chinese hamster ovary (CHO) cells and used as a model system reflecting fatal human severe genetic...

Topics

Animals
CHO Cells
Cricetinae
Cricetulus
Gene Knockout Techniques
Humans
Membrane Proteins
Mutation
PHEX Phosphate Regulating Neutral Endopeptidase
Peroxisomal Disorders
Peroxisomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Transport

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Identifiers

PMID: 28409474
DOI: 10.1007/978-1-4939-6937-1_29

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Generation of Peroxisome-Deficient Somatic Animal Cell Mutants.PMID 28409474Read ↗

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