Article
Animal cell mutants represent two complementation groups of peroxisome-defective Zellweger syndrome.
The Journal of clinical investigation - 1 Nov 1992
Shimozawa N, Tsukamoto T, Suzuki Y, Orii T, Fujiki Y
Abstract excerpt
Generalized peroxisome-deficient disorders including cerebro-hepato-renal Zellweger syndrome, neonatal adrenoleukodystrophy, and infantile Refsum disease are autosomal recessive diseases, where catalase-containing particles (peroxisomes) are morphologically absent. We previously isolated two Chinese hamster ovary (CHO) cell mutants (Z24 and Z65) that resemble the fibroblasts from patients with such diseases, in...
Topics
- Animals
- CHO Cells
- Cell Fusion
- Cricetinae
- Genetic Complementation Test
- Humans
- Microbodies
- Mutation
- Zellweger Syndrome