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Article

Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging.

PLoS computational biology - 1 Apr 2017

Yang Xiaoliang, Wang Zihua, Xiang Zhichu, Li Dan, Hu Zhiyuan, Cui Wei, Geng Lingling, Fang Qiaojun

Abstract excerpt

A high level of HER2 expression in breast cancer correlates with a higher tumor growth rate, high metastatic potential, and a poor long-term patient survival rate. Pertuzumab, a human monoclonal antibody, can reduce the effect of HER2 overexpression by preventing HER2 dimerization. In this study, a combination protocol of molecular dynamics modeling and MM/GBSA binding free energy calculations was applied to...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28406988
DOI: 10.1371/journal.pcbi.1005441
PMCID: PMC5390981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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