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Article

Highly Sensitive Droplet Digital PCR Method for Detection of EGFR-Activating Mutations in Plasma Cell-Free DNA from Patients with Advanced Non-Small Cell Lung Cancer.

The Journal of molecular diagnostics : JMD - 1 May 2015

Zhu Guanshan, Ye Xin, Dong Zhengwei, Lu Ya Chao, Sun Yun, Liu Yi, McCormack Rose, Gu Yi, Liu Xiaoqing

Abstract excerpt

Epidermal growth factor receptor (EGFR) mutation testing in plasma cell-free DNA from lung cancer patients is an emerging clinical tool. However, compared with tissue testing, the sensitivity of plasma testing is not yet satisfactory because of the highly fragmented nature of plasma cell-free DNA, low fraction of tumor DNA, and limitations of available detection technologies. We therefore developed a highly...

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PMID: 25769900
DOI: 10.1016/j.jmoldx.2015.01.004

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EGFR

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