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Article

Mutations in PMR1 stimulate xylose isomerase activity and anaerobic growth on xylose of engineered Saccharomyces cerevisiae by influencing manganese homeostasis.

Scientific reports - 12 Apr 2017

Verhoeven Maarten D, Lee Misun, Kamoen Lycka, van den Broek Marcel, Janssen Dick B, Daran Jean-Marc G, van Maris Antonius J A, Pronk Jack T

Abstract excerpt

Combined overexpression of xylulokinase, pentose-phosphate-pathway enzymes and a heterologous xylose isomerase (XI) is required but insufficient for anaerobic growth of Saccharomyces cerevisiae on d-xylose. Single-step Cas9-assisted implementation of these modifications yielded a yeast strain expressing Piromyces XI that showed fast aerobic growth on d-xylose. However, anaerobic growth required a 12-day...

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Identifiers

PMID: 28401919
DOI: 10.1038/srep46155
PMCID: PMC5388867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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