Article
The expression of a Pichia stipitis xylose reductase mutant with higher K(M) for NADPH increases ethanol production from xylose in recombinant Saccharomyces cerevisiae.
Biotechnology and bioengineering - 5 Mar 2006
Jeppsson Marie, Bengtsson Oskar, Franke Katja, Lee Hung, Hahn-Hägerdal Bärbel, Gorwa-Grauslund Marie F
Abstract excerpt
Xylose fermentation by Saccharomyces cerevisiae requires the introduction of a xylose pathway, either similar to that found in the natural xylose-utilizing yeasts Pichia stipitis and Candida shehatae or similar to the bacterial pathway. The use of NAD(P)H-dependent XR and NAD(+)-dependent XDH from P. stipitis creates a cofactor imbalance resulting in xylitol formation. The effect of replacing the native P....
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