Article
Decreased comfort food intake and allostatic load in adolescents carrying the A3669G variant of the glucocorticoid receptor gene.
Appetite - 1 Sept 2017
Rodrigues Danitsa Marcos, Reis Roberta Sena, Dalle Molle Roberta, Machado Tania Diniz, Mucellini Amanda Brondani, Bortoluzzi Andressa, Toazza Rudineia, Pérez Juliano Adams, Salum Giovanni Abrahão, Agranonik Marilyn, Minuzzi Luciano, Levitan Robert D, Buchweitz Augusto, Franco Alexandre Rosa, Manfro Gisele Gus, Silveira Patrícia Pelufo
Abstract excerpt
BACKGROUND: The A3669G single nucleotide polymorphism (SNP) of the glucocorticoid receptor (GR) gene NR3C1 is associated with altered tissue sensitivity to glucocorticoids (GCs). GCs modulate the food reward circuitry and are implicated in increased intake of palatable foods, which can lead to the metabolic syndrome and obesity. We hypothesized that presence of the G variant of the A3669G SNP would affect...
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