Article
Genetic Evidence of Endocannabinoid System on Perceived Stress and Restricted Food Intake: The Role of Variants rs324420 in FAAH Gene and rs1049353 in CNR1 Gene.
Cannabis and cannabinoid research - 1 Feb 2025
Martínez-Rodríguez Tania Yadira, Valdés-Miramontes Elia H, Muñoz-Valle José Francisco, Reyes-Castillo Zyanya
Abstract excerpt
Background: The endocannabinoid system (ECS) is active in brain regions involved in stress, food intake, and emotional regulation. The CB1 receptor and the fatty acid amide hydrolase (FAAH) enzyme regulate the ECS. Genetic variants in the FAAH gene (rs324420) and in the CNR1 gene (rs1049353) have been involved in both chronic stress and obesity. As a maladaptive strategy to evade the stress, three dysfunctional...
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