Article
Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia.
Journal of hematology & oncology - 11 Apr 2017
Quijada-Álamo Miguel, Hernández-Sánchez María, Robledo Cristina, Hernández-Sánchez Jesús-María, Benito Rocío, Montaño Adrián, Rodríguez-Vicente Ana E, Quwaider Dalia, Martín Ana-África, García-Álvarez María, Vidal-Manceñido María Jesús, Ferrer-Garrido Gonzalo, Delgado-Beltrán María-Pilar, Galende Josefina, Rodríguez Juan-Nicolás, Martín-Núñez Guillermo, Alonso José-María, García de Coca Alfonso, Queizán José A, Sierra Magdalena, Aguilar Carlos, Kohlmann Alexander, Hernández José-Ángel, González Marcos, Hernández-Rivas Jesús-María
Abstract excerpt
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a highly genetically heterogeneous disease. Although CLL has been traditionally considered as a mature B cell leukemia, few independent studies have shown that the genetic alterations may appear in CD34+ hematopoietic progenitors. However, the presence of both chromosomal aberrations and gene mutations in CD34+ cells from the same patients has not been explored....
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