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Endothelial cell dysfunction and glycocalyx - A vicious circle.

Matrix biology : journal of the International Society for Matrix Biology - 1 Oct 2018

Zhang Xiaohui, Sun Dong, Song Jeon W, Zullo Joseph, Lipphardt Mark, Coneh-Gould Leona, Goligorsky Michael S

Abstract excerpt

Dysfunctional endothelial cells are an essential contributor to the progression of diverse chronic cardiovascular, renal, and metabolic diseases. It manifests in impairment of nitric oxide-dependent vasorelaxation, vascular permeability, and leukocytes deterrent. While endothelial glycocalyx is known to regulate these functions, glycocalyx has been shown to be impaired in pathologic settings leading to...

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PMID: 29408548
DOI: 10.1016/j.matbio.2018.01.026

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