Article
Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2018
Kiyohara Takuya, Miyano Kei, Kamakura Sachiko, Hayase Junya, Chishiki Kanako, Kohda Akira, Sumimoto Hideki
Abstract excerpt
Transmembrane glycoproteins, synthesized at the endoplasmic reticulum (ER), generally reach the Golgi apparatus in COPII-coated vesicles en route to the cell surface. Here, we show that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which...
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